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Tue, 20 Oct, 2026Updated 08:07 pm IST
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Christina Applegate Misdiagnosed

Actress reveals she doesn't have multiple sclerosis after years of treatment, despite still experiencing symptoms

Christina Applegate Misdiagnosed
Photo: Filipe Braggio / Pexels

Christina Applegate has revealed that she was misdiagnosed with multiple sclerosis (MS) and does not actually have the disease. The actress, who was initially diagnosed in August 2021 at the age of 49, made the announcement on her podcast 'MeSsY', which she co-hosts with Jamie-Lynn Sigler, who has MS.

Applegate had been experiencing symptoms similar to those of MS for years before her initial diagnosis and had undergone infusions as part of her treatment plan. However, after new technology around brain MRIs was used, her doctor told her that she did not have MS. Applegate expressed feelings of anger and confusion upon receiving the news, as she still experiences symptoms similar to those of MS.

According to Doctor Marwa Kaisey, a neurologist at Cedars-Sinai Medical Center, 1 in 5 people are misdiagnosed with MS. Kaisey explained that this is because there is no single test for MS, and diagnosis is based on a list of criteria. Applegate's misdiagnosis highlights the challenges of diagnosing MS and the importance of ongoing medical evaluation.

Applegate's symptoms have gotten worse over time, despite the misdiagnosis. She had been leaning on the MS community, including her co-host Jamie-Lynn Sigler, who was diagnosed with MS in 2001. Applegate's experience serves as a reminder that misdiagnosis can have significant consequences for patients, including unnecessary treatment and emotional distress.

## What happens next Applegate's announcement has sparked a conversation about the importance of accurate diagnosis and the need for ongoing medical evaluation. As she navigates this new information, Applegate will likely continue to seek medical attention to determine the cause of her symptoms. Her experience highlights the complexities of diagnosing MS and the importance of advocating for oneself in the medical system.

The misdiagnosis of MS is a significant issue, with 1 in 5 people being misdiagnosed. This can lead to unnecessary treatment, emotional distress, and delayed diagnosis of the actual condition. Applegate's story serves as a reminder of the importance of seeking a second opinion and advocating for oneself in the medical system.

Sources

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