Blood Pressure Drug Shows Promise in Treating ADHD
Amlodipine, a common medication for hypertension, has significant effects on rat and zebrafish behavior, suggesting it could be a viable alternative to existing ADHD treatments
A common blood pressure drug, amlodipine, has shown potential in treating ADHD in animal studies, with significant effects on rat and zebrafish behavior. Around a quarter of patients with ADHD find that existing medications for the condition do not improve their symptoms, highlighting the need for alternative treatments.
A team of researchers from institutions across Europe found that amlodipine could be a good candidate for treating ADHD. In an initial experiment, seven groups of spontaneously hypertensive rats were given a regimen of a different treatment, and amlodipine was the only drug that had a significant effect on rat behavior. The rats were administered amlodipine daily for 30 days, resulting in notable changes in their behavior.
The researchers also tested amlodipine on genetically modified zebrafish with hyperactive traits, which are often used as a model for ADHD in humans. The results showed that amlodipine reduced impulsivity in the zebrafish, with effects similar to those of methylphenidate (Ritalin), a commonly prescribed ADHD medication. Both amlodipine and methylphenidate had significant effects on curbing impulsive behaviors in the zebrafish.
Further analysis of existing UK Biobank data found that people taking amlodipine for hypertension were less likely to report mood swings or risk-taking, suggesting that the medication may have a positive impact on ADHD symptoms in humans.
## Why it matters The study's findings are significant, as they suggest that amlodipine could be a viable alternative to existing ADHD medications, which can have significant side effects. The need for new treatments is pressing, as many patients with ADHD do not respond to current medications or experience adverse effects. While the results are promising, human clinical trials are needed to determine the effectiveness of amlodipine in treating ADHD.
The potential of amlodipine as an ADHD treatment is a significant development, as it could provide a new option for patients who do not respond to existing medications. Further research is necessary to fully explore the potential of amlodipine, but the initial findings suggest that it could be a valuable addition to the range of treatments available for ADHD.
